Serum Klotho Levels in Trained Athletes

BACKGROUND Klotho is an anti-aging protein that is predominantly secreted by the kidneys. OBJECTIVES The aim of the study was to measure and compare the circulating Klotho levels in the serum of trained athletes and in healthy, non-athlete controls. MATERIALS AND METHODS Thirty trained football players were enrolled and their serum Klotho levels were measured the morning after their last evening exercise training. RESULTS The plasma free Klotho concentration was significantly higher in the athlete group (3.375 ± 1.48 ng/mL) compared to the non-athletes (1.39 ± 0.43 ng/mL) (P < 0.05). Serum levels of cholesterol, triglycerides, calcium, and phosphorus were not significantly different between the two groups. CONCLUSIONS Regular aerobic exercise could increase plasma Klotho levels, and this could be an explanation for exercise-related anti-aging effects.